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SGPL1 antibody (AA 60-390)

SGPL1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7270533
  • Target See all SGPL1 Antibodies
    SGPL1 (Sphingosine-1-Phosphate Lyase 1 (SGPL1))
    Binding Specificity
    • 8
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 60-390
    Reactivity
    • 32
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 32
    • 2
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SGPL1 antibody is un-conjugated
    Application
    • 26
    • 17
    • 16
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    SGPL1 Rabbit pAb
    Sequence
    VFQPESLWSR FKKKCFKLTR KMPIIGRKIQ DKLNKTKDDI SKNMSFLKVD KEYVKALPSQ GLSSSAVLEK LKEYSSMDAF WQEGRASGTV YSGEEKLTEL LVKAYGDFAW SNPLHPDIFP GLRKIEAEIV RIACSLFNGG PDSCGCVTSG GTESILMACK AYRDLAFEKG IKTPEIVAPQ SAHAAFNKAA SYFGMKIVRV PLTKMMEVDV RAMRRAISRN TAMLVCSTPQ FPHGVIDPVP EVAKLAVKYK IPLHVDACLG GFLIVFMEKA GYPLEHPFDF RVKGVTSISA DTHKYGYAPK GSSLVLYSDK KYRNYQFFVD TDWQGGIYAS P
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_003892.2).
    Isotype
    IgG
    Top Product
    Discover our top product SGPL1 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SGPL1 (Sphingosine-1-Phosphate Lyase 1 (SGPL1))
    Alternative Name
    SGPL1 (SGPL1 Products)
    Synonyms
    SGPL1 antibody, zgc:162153 antibody, AI428538 antibody, D10Xrf456 antibody, S1PL antibody, Spl antibody, SPL antibody, Spgl1 antibody, spl antibody, sphingosine-1-phosphate lyase 1 antibody, sphingosine-1-phosphate lyase 1 L homeolog antibody, sphingosine phosphate lyase 1 antibody, SGPL1 antibody, sgpl1.L antibody, sgpl1 antibody, Sgpl1 antibody
    Background
    Cleaves phosphorylated sphingoid bases (PSBs, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity. Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity.,SGPL1,S1PL,SPL,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Lipid Metabolism,Cardiovascular,Lipids,Fatty Acids,SGPL1
    Molecular Weight
    63kDa
    Gene ID
    8879
    UniProt
    O95470
    Pathways
    Platelet-derived growth Factor Receptor Signaling
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