SF3B1 antibody (pThr313)

Catalog No. ABIN7270541

The Rabbit Polyclonal anti-SF3B1 antibody has been validated for WB. It is suitable to detect SF3B1 in samples from Human.

Quick Overview for SF3B1 antibody (pThr313) (ABIN7270541)

Target: SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SF3B1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SF3B1 Antibody

Binding Specificity: pThr313

Purpose: Phospho-SF3B1-T313 Rabbit pAb

Sequence: AETPR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around T313 of human SF3B1 (NP_036565.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SF3B1

Target: SF3B1 (Splicing Factor 3b, Subunit 1, 155kDa (SF3B1))

Alternative Name: SF3B1

Background: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.,SF3B1,Hsh155,MDS,PRP10,PRPF10,SAP155,SF3b155,Epigenetics & Nuclear Signaling,RNA Binding,Protein phosphorylation,SF3B1

Molecular Weight: 16kDa/145kDa

Gene ID: 23451

UniProt: O75533

Pathways: Chromatin Binding