TXNRD1 antibody

Catalog No. ABIN7270805

The Rabbit Monoclonal anti-TXNRD1 antibody has been validated for WB. It is suitable to detect TXNRD1 in samples from Human.

Quick Overview for TXNRD1 antibody (ABIN7270805)

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TXNRD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TXNRD1 Antibody

Purpose: Thioredoxin reductase 1 (TXNRD1 ) Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Thioredoxin reductase 1 (Thioredoxin reductase 1 (TXNRD1 ) )

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TXNRD1

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Alternative Name: TXNRD1

Background: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008],GRIM-12, TR, TR1, TRXR1, TXNR,Cancer,Cell Biology & Developmental Biology,Endocrine & Metabolism,Signal Transduction,TXNRD1

Molecular Weight: 55kDa

Gene ID: 7296

UniProt: Q16881

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis