TXNRD1 antibody (AA 161-647)

Catalog No. ABIN5776265

The Mouse Monoclonal anti-TXNRD1 antibody (Clone AT30F1) (ABIN5776265) specifically detects TXNRD1 in WB, ELISA, ICC and IF. The antibody is reactive with Human samples.

Quick Overview for TXNRD1 antibody (AA 161-647) (ABIN5776265)

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TXNRD1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: AT30F1

Product Details anti-TXNRD1 Antibody

Binding Specificity: AA 161-647

Purpose: Human Thioredoxin Reductase 1/TRXR1 antibody

Purification: Purified

Immunogen: Recombinant human TXNRD1 (161-647aa) purified from E. coli

Isotype: IgG2b kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing cycles

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Target Details for TXNRD1

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Alternative Name: Thioredoxin Reductase 1/TRXR1

Background: TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotidedisulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

NCBI Accession: NP_001087240

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis