USP37 antibody (AA 150-250)

Catalog No. ABIN7271158

This Rabbit Polyclonal antibody specifically detects USP37 in WB. It exhibits reactivity toward Human.

Quick Overview for USP37 antibody (AA 150-250) (ABIN7271158)

Target: USP37 (Ubiquitin Specific Peptidase 37 (USP37))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP37 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-USP37 Antibody

Binding Specificity: AA 150-250

Purpose: USP37 Rabbit pAb

Sequence: SLETKDDIPF RKVLGNPGRG SIKTVAGSGI ARTIPSLTST STPLRSGLLE NRTEKRKRMI STGSELNEDY PKENDSSSNN KAMTDPSRKY LTSSREKQLS L

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human USP37 (NP_065986.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for USP37

Target: USP37 (Ubiquitin Specific Peptidase 37 (USP37))

Alternative Name: USP37

Background: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2, thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2. Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1.,USP37,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Ubiquitin,USP37

Molecular Weight: 99kDa/110kDa

Gene ID: 57695

UniProt: Q86T82