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USP37 antibody (Internal Region)

USP37 Reactivity: Human, Rat ELISA, ICC, IF, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6257545
$390.77
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  • Target See all USP37 Antibodies
    USP37 (Ubiquitin Specific Peptidase 37 (USP37))
    Binding Specificity
    • 9
    • 9
    • 8
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 35
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat
    Host
    • 35
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 17
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    This USP37 antibody is un-conjugated
    Application
    • 26
    • 24
    • 5
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    USP37 Antibody detects endogenous levels of total USP37.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human USP37, corresponding to a region within the internal amino acids.
    Isotype
    IgG
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    USP37 (Ubiquitin Specific Peptidase 37 (USP37))
    Alternative Name
    USP37 (USP37 Products)
    Synonyms
    4932415L06Rik antibody, C330008N13Rik antibody, wu:fi15b04 antibody, wu:fi38d03 antibody, zgc:152882 antibody, zgc:153999 antibody, ubiquitin specific peptidase 37 antibody, USP37 antibody, usp37 antibody, Usp37 antibody
    Background

    Description: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).

    Gene: USP37

    Molecular Weight
    ?120 kDa
    Gene ID
    57695
    UniProt
    Q86T82
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