PRMT5 antibody

Catalog No. ABIN7383995

This Rabbit Polyclonal antibody specifically detects PRMT5 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PRMT5 antibody (ABIN7383995)

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRMT5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PRMT5 Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human PRMT5

Isotype: IgG

Application Details

Application Notes: WB 1:200-1:1000

Restrictions: For Research Use only

Handling

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PRMT5

Target: PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))

Alternative Name: PRMT5

Background: 72 kDa ICln binding protein,72 kDa ICln-binding protein,ANM5,Histone synthetic lethal 7,S. cerevisiae,homolog of,Histone-arginine N-methyltransferase PRMT5,HMT1 hnRNP methyltransferase like 5,HOMOLOG OF,SKB1,HRMT1L5,IBP72,Jak-binding protein 1,JBP 1,JBP1,PRMT 5,PRMT5,Protein arginine methyltransferase 5,Protein arginine N methyltransferase 5,Protein arginine N methyltransferase 5 N terminally processed,Protein arginine N-methyltransferase 5,S. POMBE,S. POMBE HOMOLOG OF,SKB1,SHK1 KINASE BINDING PROTEIN 1,Shk1 kinase binding protein 1 homolog,Shk1 kinase-binding protein 1 homolog,Shk1 kinase/binding protein 1,S. pombe,homolog of,SKB 1,SKB1,SKB1 homolog,SKB1: SKB1 homolog (S. pombe),SKB1Hs,Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.

Molecular Weight: 71 kDa

NCBI Accession: NP_001034708

UniProt: O14744

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development