Beclin 1 antibody

Catalog No. ABIN7384332

The Rabbit Monoclonal anti-Beclin 1 antibody has been validated for WB. It is suitable to detect Beclin 1 in samples from Human, Mouse and Rat.

Quick Overview for Beclin 1 antibody (ABIN7384332)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R02-8D5

Product Details anti-Beclin 1 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: Beclin 1

Background: APG6,ATG 6,ATG6,ATG6 autophagy related 6 homolog,Bcl-2-interacting protein beclin,Beclin 1 (coiled coil moesin like BCL2 interacting protein),Beclin 1 autophagy related,Beclin-1,Beclin1,BECN 1,Becn1,BECN1,Coiled coil myosin like BCL2 interacting protein,Coiled-coil myosin-like BCL2-interacting protein,GT197,Protein GT197,VPS 30,VPS30,Beclin-1 (BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.

Molecular Weight:

Observed_MW: 52kDa

Calculated_MW: 52kDa

Gene ID: 8678

UniProt: Q14457

Pathways: Autophagy