COL1A1 antibody

Catalog No. ABIN7384384

The Rabbit Monoclonal anti-COL1A1 antibody (Clone R02-5E5) (ABIN7384384) specifically detects COL1A1 in WB. The antibody is reactive with Human samples.

Quick Overview for COL1A1 antibody (ABIN7384384)

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This COL1A1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R02-5E5

Product Details anti-COL1A1 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COL1A1

Target: COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

Alternative Name: Collagen I alpha 1

Background: COL1A1,Alpha 1 type I collagen,Alpha-1 type I collagen,CO1A1,COL1A1,Collagen alpha-1(I) chain,Collagen type I alpha 1,Procollagen type I C terminal propeptide,COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I. Among its related pathways are Collagen chain trimerization and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include identical protein binding and platelet-derived growth factor binding. An important paralog of this gene is COL2A1.This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Molecular Weight:

Observed_MW: 139kDa

Calculated_MW: 139kDa

Gene ID: 1277

UniProt: P02452

Pathways: Sensory Perception of Sound, Autophagy, Growth Factor Binding