FAS antibody

Catalog No. ABIN7384441

The Rabbit Monoclonal anti-FAS antibody (Clone R02-8I7) (ABIN7384441) specifically detects FAS in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for FAS antibody (ABIN7384441)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This FAS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R02-8I7

Product Details anti-FAS Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000 IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: Fas

Background: ALPS 1A,ALPS1A,APO 1,Apo 1 antigen,APO 1 cell surface antigen,Apo-1 antigen,APO1,Apo1 antigen,APO1 cell surface antigen,Apoptosis antigen 1,Apoptosis mediating surface antigen FAS,Apoptosis-mediating surface antigen FAS,APT 1,APT1,CD 95,CD 95 antigen,CD95,CD95 antigen,Delta Fas,Delta Fas/APO 1/CD95,Delta Fas/APO1/CD95,Fas (TNF receptor superfamily,member 6),FAS 1,FAS 827dupA,Fas AMA,Fas,FAS Antigen,Fas cell surface death receptor,FAS1,FASLG receptor,FASTM,sFAS,Surface antigen APO1,TNF receptor superfamily,member 6,TNFRSF 6,TNFRSF6,TNR6,Tumor necrosis factor receptor superfamily member 6,FAS,also named as CD95,APO-1,APT1,FAS1 and TNFRSF6,is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily,can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). This anti-Fas monoclonal antibody can be used to induce apoptosis in cell cultures through Fas by imitating the Fas-ligand.

Molecular Weight:

Observed_MW: 45kDa

Calculated_MW: 38kDa

Gene ID: 355

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity