MLH1 antibody

Catalog No. ABIN7384468

The Rabbit Monoclonal anti-MLH1 antibody (Clone R02-2E8) (ABIN7384468) specifically detects MLH1 in WB and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MLH1 antibody (ABIN7384468)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MLH1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: R02-2E8

Product Details anti-MLH1 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000 IF 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Alternative Name: MLH1

Background: COCA 2,COCA2,DNA mismatch repair protein Mlh1,FCC 2,FCC2,hMLH 1,hMLH1,HNPCC 2,HNPCC,HNPCC2,MGC5172,MLH 1,MLH1,MLH1,MutL homolog 1 (E. coli),MutL homolog 1,MutL homolog 1 colon cancer nonpolyposis type 2,MutL homolog 1,colon cancer,nonpolyposis type 2 (E. coli),MutL protein homolog 1,MutL,E. coli,homolog of,1,This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Molecular Weight:

Observed_MW: 85kDa

Calculated_MW: 85kDa

Gene ID: 4292

UniProt: P40692

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response