PTBP1 antibody

Catalog No. ABIN7384487

This Rabbit Monoclonal antibody specifically detects PTBP1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Hamster.

Quick Overview for PTBP1 antibody (ABIN7384487)

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Reactivity: Human, Mouse, Hamster

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PTBP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R01-1G2

Product Details anti-PTBP1 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:3000 IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PTBP1

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Alternative Name: PTBP1

Background: PTBP1,HNRNP-I,HNRNPI,HNRPI,PTB,PTB-1,PTB-T,PTB2,PTB3,PTB4,pPTB,This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight:

Observed_MW: 57 kDa

Calculated_MW: 57 kDa

Gene ID: 5725

UniProt: P26599

Pathways: Regulation of Muscle Cell Differentiation