Recombinant MUC16 (Sofituzumab Biosimilar) antibody

Catalog No. ABIN7488033

The Mammalian Cells Monoclonal anti-MUC16 (Sofituzumab Biosimilar) antibody (ABIN7488033) specifically detects MUC16 (Sofituzumab Biosimilar) in ELISA. The antibody is reactive with Human samples.

Quick Overview for Recombinant MUC16 (Sofituzumab Biosimilar) antibody (ABIN7488033)

Target: MUC16 (Sofituzumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mammalian Cells

Clonality: Monoclonal

Conjugate: This MUC16 (Sofituzumab Biosimilar) antibody is un-conjugated

Application: ELISA

Grade: Research Grade

Product Details anti-MUC16 (Sofituzumab Biosimilar) Antibody

Expression System: Mammalian cells

Purpose: Sofituzumab Biosimilar - Anti-MUC16, CA125 mAb

Characteristics: Antibody Type: IgG1-kappa

Purification: Recombinant antibody expressed in mammalien cells and purified.

Isotype: IgG1 kappa

Application Details

Restrictions: For Research Use only

Handling

Buffer: PBS pH 7.5

Storage: -80 °C

Storage Comment: store at -80°C

Target Details for MUC16 (Sofituzumab Biosimilar)

Target: MUC16 (Sofituzumab Biosimilar)

Target Type: Biosimilar

Background: DMUC5754A (conjugate),MMUC1206A (nonconjugate)
Sofituzumab is investigated for the treatment of Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer. Sofituzumab Vedotin (also known as DMUC5754A and RG-7458) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody (mAb) and a potent anti-mitotic agent, monomethyl auristatin E (MMAE), linked through a protease-labile linker, maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl. DMUC5754A binds to the MUC16 extracellular domain with high affinity, and shows potent and selective anti-tumor activity in MUC16-expressing human ovarian cancer (OC) and pancreatic cancer (PC) mouse xenograft models. The targeted therapeutic strategy of DMUC5754A resulted in enhanced tumor-specific activity of MMAE, while minimizing exposure to tissues that do not express MUC16.

CAS-No: 1418200-58-4