AKAP8 antibody (C-Term)

Catalog No. ABIN7448405

The Rabbit Polyclonal anti-AKAP8 antibody has been validated for IHC. It is suitable to detect AKAP8 in samples from Human and Mouse.

Quick Overview for AKAP8 antibody (C-Term) (ABIN7448405)

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP8 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-AKAP8 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-AKAP8/AKAP95 IHC Antibody, Affinity Purified

Predicted Reactivity: Bovine,Gorilla,Chimpanzee

Purification: Affinity Purified

Immunogen: Between AA 642 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for AKAP8

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Alternative Name: AKAP8/AKAP95

Background: Background: AKAP8/AKAP95 has been characterized as a 95 kDa protein kinase A (PKA)-anchoring protein and regulatory subunit of PKA that functions to recruit the condensin complex for chromosome condensation during mitosis. A role in DNA replication has also been demonstrated through its interaction with the pre-replication complex component, MCM2 (mini-chromosome maintenance 2). Inhibition of AKAP8/AKAP95 association with MCM2 inhibits replication initiation and elongation in vitro. AKAP8/AKAP95 has also been shown to be involved in apoptosis. KAP8/AKAP95 associates with caspase 3 and serves as a carrier to transport caspase 3 from the cytoplasm to the nucleus to induce morphological changes in the nucleus.

Gene ID: 10270

NCBI Accession: NP_005849

UniProt: O43823

Pathways: SARS-CoV-2 Protein Interactome