MCM2 antibody (pSer40, pSer41)

Catalog No. ABIN7448650

This Rabbit Polyclonal antibody specifically detects MCM2 in IHC. It exhibits reactivity toward Human and Mouse.

Quick Overview for MCM2 antibody (pSer40, pSer41) (ABIN7448650)

Target: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MCM2 Antibody

Binding Specificity: pSer40, pSer41

Purpose: Rabbit anti-Phospho MCM2 (S40/S41) IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,X. laevis,X. tropicalis,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,African elephant,White-tufted-ear marmoset,Little brown bat,Chinese hamster,Naked mole rat,Duckbill platypus,Tasmanian devil,Small-eared galago,Crab-eating macaque,Gray short-tailed opossum,West Indian ocean coelacanth,Green anole

Purification: Affinity Purified

Immunogen: Surrounding serine 40/41

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MCM2

Target: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Alternative Name: MCM2

Background: Background: The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM2 interacts with the core MCM complex (MCM4, 6, and 7) to regulate its helicase activity.

Gene ID: 4171

NCBI Accession: NP_004517

UniProt: P49736

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA