MTA3 antibody (AA 400-450)

Catalog No. ABIN7448677

This Rabbit Polyclonal antibody specifically detects MTA3 in IHC. It exhibits reactivity toward Human.

Quick Overview for MTA3 antibody (AA 400-450) (ABIN7448677)

Target: MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTA3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MTA3 Antibody

Binding Specificity: AA 400-450

Purpose: Rabbit anti-MTA3 IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Northern white-cheeked gibbon,Small-eared galago

Purification: Affinity Purified

Immunogen: Between AA 400 and 450

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MTA3

Target: MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))

Alternative Name: MTA3

Background: Background: MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.

Gene ID: 57504

NCBI Accession: NP_001317371

UniProt: Q9BTC8

Pathways: Chromatin Binding