PCSK2 antibody (AA 150-200)

Catalog No. ABIN7448718

The Rabbit Polyclonal anti-PCSK2 antibody (ABIN7448718) specifically detects PCSK2 in IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for PCSK2 antibody (AA 150-200) (ABIN7448718)

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCSK2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PCSK2 Antibody

Binding Specificity: AA 150-200

Purpose: Rabbit anti-Pc2 IHC Antibody, Affinity Purified

Predicted Reactivity: Bovine,Dog,Rabbit,Guinea pig_10141,Pig,Panda,Monkey,Gorilla,Chimpanzee,Tasmanian devil,White-tufted-ear marmoset,Gray short-tailed opossum,Small-eared galago,Thirteen-lined ground squirrel,Chinese hamster,Naked mole rat,Little brown bat

Purification: Affinity Purified

Immunogen: Between AA 150 and 200

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PCSK2

Target: PCSK2 (Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2))

Alternative Name: Pc2

Background: Background: Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) O00257].

Gene ID: 8535

NCBI Accession: NP_003646

UniProt: O00257

Pathways: Peptide Hormone Metabolism, cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity