Prohibitin 2 antibody (AA 1-50)

Catalog No. ABIN7448768

The Rabbit Polyclonal anti-Prohibitin 2 antibody has been validated for IHC. It is suitable to detect Prohibitin 2 in samples from Human.

Quick Overview for Prohibitin 2 antibody (AA 1-50) (ABIN7448768)

Target: Prohibitin 2 (PHB2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prohibitin 2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Prohibitin 2 Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-REA IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rabbit,Guinea pig_10141,Orangutan,Monkey,Gorilla,Thirteen-lined ground squirrel,White-tufted-ear marmoset,Small-eared galago,Northern white-cheeked gibbon,Naked mole rat,African elephant

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Prohibitin 2

Target: Prohibitin 2 (PHB2)

Alternative Name: REA

Background: Background: REA (repressor of estrogen receptor activity), also known as prohibitin 2, has been shown to exhibit a variety of functions that includes mitochondrial chaperone activity, cell cycle regulation, and transcriptional regulation. REA localizes to the mitochondria and associates with mitochondrial complex I where it may play a role in mitochondrial metabolism. REA interacts with pRb to inhibit E2F-mediated transcription as well as the estrogen receptor to repress estrogen-dependent transcription via recruitment of histone deacetylases.

Gene ID: 11331

NCBI Accession: NP_009204

UniProt: Q99623

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling