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SYK antibody (AA 250-300)

This Rabbit Polyclonal antibody specifically detects SYK in IHC. It exhibits reactivity toward Human.
Catalog No. ABIN7448821

Quick Overview for SYK antibody (AA 250-300) (ABIN7448821)

Target

See all SYK Antibodies
SYK (Spleen tyrosine Kinase (SYK))

Reactivity

  • 168
  • 86
  • 55
  • 10
  • 5
  • 5
  • 4
  • 3
  • 3
  • 1
  • 1
Human

Host

  • 159
  • 14
  • 3
Rabbit

Clonality

  • 160
  • 15
Polyclonal

Conjugate

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  • 3
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  • 2
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  • 2
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  • 2
This SYK antibody is un-conjugated

Application

  • 138
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  • 22
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  • 19
  • 14
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  • 6
  • 4
  • 3
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  • 2
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  • 1
  • 1
Immunohistochemistry (IHC)
  • Binding Specificity

    • 34
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    • 19
    • 13
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    • 8
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    • 5
    • 4
    • 4
    • 4
    • 3
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    • 1
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    • 1
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    • 1
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    • 1
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    AA 250-300

    Purpose

    Rabbit anti-SYK IHC Antibody, Affinity Purified

    Predicted Reactivity

    Orangutan,Monkey,Gorilla,Chimpanzee,Northern white-cheeked gibbon,Crab-eating macaque

    Purification

    Affinity Purified

    Immunogen

    Between AA 250 and 300

    Isotype

    IgG
  • Application Notes

    1:100 - 1:500

    Restrictions

    For Research Use only
  • Concentration

    250 μg/mL

    Buffer

    Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Expiry Date

    12 months
  • Target

    SYK (Spleen tyrosine Kinase (SYK))

    Alternative Name

    SYK

    Background

    Background: SYK (spleen tyrosine kinase) is a ubiquitously expressed tyrosine kinase that functions in mediating B and T-cell receptor signaling and is also important to various aspects of leukocyte function that involve cytoskeleton remodeling. In mediating hematopoietic cell signaling, SYK is a substrate of src family kinase activity and is a key-regulator of Akt kinase activity. SYK has also been found to be highly expressed in the mammary gland and has been shown to inhibit tumor growth and metastasis. Invasive breast tumor cell lines have been shown to exhibit reduced or absent levels of SYK, further implicating a role in tumorigenesis and metastasis.

    Gene ID

    6850

    NCBI Accession

    NP_003168

    UniProt

    P43405

    Pathways

    Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling
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