Vinculin antibody (AA 1016-1066)

Catalog No. ABIN7448859

The Rabbit Polyclonal anti-Vinculin antibody (ABIN7448859) specifically detects Vinculin in IHC. The antibody is reactive with Human samples.

Quick Overview for Vinculin antibody (AA 1016-1066) (ABIN7448859)

Target: Vinculin (VCL)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Vinculin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Vinculin Antibody

Binding Specificity: AA 1016-1066

Purpose: Rabbit anti-Vinculin IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Zebrafish,Chicken,Turkey,Bovine,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,White-tufted-ear marmoset,Tasmanian devil,Duckbill platypus,Crab-eating macaque,Medaka fish,Small-eared galago,Japanese pufferfish,Thirteen-lined ground squirrel,Green anole,Gray short-tailed opossum,Chinese hamster,Naked mole rat,Northern white-cheeked gibbon,Nile tilapia,African elephant,Spotted green pufferfish,Little brown bat,Zebra finch,Three-spined stickleback

Purification: Affinity Purified

Immunogen: Between AA 1016 and 1066

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Vinculin

Target: Vinculin (VCL)

Alternative Name: Vinculin

Background: Background: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in vinculin are the cause of cardiomyopathy dilated type 1W, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia [taken from NCBI Entrez Gene (GeneID: 7414)].

Gene ID: 7414

NCBI Accession: NP_003364

UniProt: P18206

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2