BMI1 antibody (AA 276-326)

Catalog No. ABIN7448885

The Rabbit Polyclonal anti-BMI1 antibody has been validated for IHC. It is suitable to detect BMI1 in samples from Human and Mouse.

Quick Overview for BMI1 antibody (AA 276-326) (ABIN7448885)

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMI1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-BMI1 Antibody

Binding Specificity: AA 276-326

Purpose: Rabbit anti-BMI1 IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,X. tropicalis,Chicken,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Cat,Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque,African elephant,Tasmanian devil,Gray short-tailed opossum,Small-eared galago,Naked mole rat,Zebra finch,Chinese hamster,Duckbill platypus,White-tufted-ear marmoset,Little brown bat,Northern white-cheeked gibbon,Thirteen-lined ground squirrel

Purification: Affinity Purified

Immunogen: Between AA 276 and 326

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Alternative Name: BMI1

Background: Background: BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) is a core component of the polycomb group (PcG) multiprotein PRC1 complex which plays an important role in transcriptional repression of gene expression during development. BMI1 association with RING protein 1B is important to the E3 ligase activity of RING1B in the PRC1 complex. BMI1 is an oncogene whose overexpression is associated with many types of human tumors and is a stem-cell marker and regulator of stem cell self-renewal.

Gene ID: 648

NCBI Accession: NP_005171

UniProt: P35226

Pathways: Cell Division Cycle, Autophagy