CHD8 antibody (AA 2252-2302)

Catalog No. ABIN7448888

The Rabbit Polyclonal anti-CHD8 antibody is suitable to detect CHD8 in samples from Human. It has been validated for IHC.

Quick Overview for CHD8 antibody (AA 2252-2302) (ABIN7448888)

Target: CHD8 (Chromodomain Helicase DNA Binding Protein 8 (CHD8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHD8 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-CHD8 Antibody

Binding Specificity: AA 2252-2302

Purpose: Rabbit anti-CHD8 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Bovine,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,African elephant,Tasmanian devil,Crab-eating macaque,Naked mole rat,Small-eared galago,Thirteen-lined ground squirrel,White-tufted-ear marmoset,Little brown bat,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 2252 and 2302

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CHD8

Target: CHD8 (Chromodomain Helicase DNA Binding Protein 8 (CHD8))

Alternative Name: CHD8

Background: Background: CHD8 is a member of the CHD (chromodomain-helicase-DNA-binding) family of proteins that interacts with nucleosomes and plays a role in chromatin remodeling to modulate transcription. The members of the CHD family of proteins possess 3 common structural and functional domains: a chromodomain (chromatin organization modifier), an SNF2-like helicase/ATPase domain, and a C-terminal DNA-binding domain. CHD8 has been reported to interact with duplin, a protein involved in the wnt signaling pathway, and CTCF, a protein involved in heterochromatin formation.

Gene ID: 57680

NCBI Accession: NP_065971

UniProt: Q9HCK8

Pathways: Chromatin Binding