CBR1 antibody (AA 227-277)

Catalog No. ABIN7450066

This Rabbit Polyclonal antibody specifically detects CBR1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for CBR1 antibody (AA 227-277) (ABIN7450066)

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-CBR1 Antibody

Binding Specificity: AA 227-277

Purpose: Rabbit anti-Carbonyl Reductase 1/CBR1 Antibody, Affinity Purified

Predicted Reactivity: Orangutan

Purification: Affinity Purified

Immunogen: Between AA 227 and 277

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CBR1

Target: CBR1 (Carbonyl Reductase 1 (CBR1))

Alternative Name: Carbonyl Reductase 1/CBR1

Background: Background: Carbonyl Reductase 1 / CBR1 is an NADPH-dependent reductase with broad substrate specificity. It catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. It also catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Carbonyl Reductase 1 / CBR1 can convert prostaglandin E2 to prostaglandin F2-alpha [taken from the Universal Protein Resource (UniProt) P16152].

Gene ID: 873

NCBI Accession: NP_001748

UniProt: P16152