RFWD2 antibody (AA 1-50)

Catalog No. ABIN7450133

The Rabbit Polyclonal anti-RFWD2 antibody is suitable to detect RFWD2 in samples from Human and Mouse. It has been validated for WB and IP.

Quick Overview for RFWD2 antibody (AA 1-50) (ABIN7450133)

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFWD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RFWD2 Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RFWD2

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Alternative Name: COP1/RFWD2

Background: Background: Constitutive photomorphogenic protein 1 (COP1) has been characterized in plants as a RING-finger-containing protein that functions to repress plant photomorphogenesis. In mammals, COP1 has been identified as an E3 ubiquitin ligase that negatively regulates p53 protein levels in unstressed cells. In response to DNA damage COP1 is phosphorylated by the ataxia telangiectasia mutated (ATM) protein kinase and is rapidly degraded releasing p53 to exert its tumor suppressor activities.

Gene ID: 64326

NCBI Accession: NP_071902

UniProt: Q8NHY2

Pathways: Photoperiodism