Cyclin L2 antibody (AA 470-520)

Catalog No. ABIN7450148

The Rabbit Polyclonal anti-Cyclin L2 antibody has been validated for WB and IP. It is suitable to detect Cyclin L2 in samples from Human.

Quick Overview for Cyclin L2 antibody (AA 470-520) (ABIN7450148)

Target: Cyclin L2 (CCNL2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin L2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Cyclin L2 Antibody

Binding Specificity: AA 470-520

Purpose: Rabbit anti-Cyclin L2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 470 and 520

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Cyclin L2

Target: Cyclin L2 (CCNL2)

Alternative Name: Cyclin L2

Background: Background: Cyclin L2 is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression and transcription. The hallmark characteristic of cyclins is the periodicity of their expression and activity that is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin L2 is part of a group of cyclins that are involved in transcriptional regulation at the level of RNA transcription, initiation, elongation, and RNA processing. The transcriptional regulating cyclins include cyclin C, H, K, L1, L2, T1, and T2 which associate with CDK7, -8, -9, -10 and -12. Cyclin L2 associates with CDK11 and RNA polymerase II and co-localizes with splicing factors and is implicated to play a role in pre-mRNA splicing.

Gene ID: 81669

NCBI Accession: NP_112199

UniProt: Q96S94