ZBTB33 antibody (AA 622-672)

Catalog No. ABIN7450384

Product Details anti-ZBTB33 Antibody

Target: ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))

Binding Specificity: AA 622-672

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZBTB33 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-Kaiso Antibody, Affinity Purified

Predicted Reactivity: Mouse

Purification: Affinity Purified

Immunogen: between AA 622 and 672

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ZBTB33

Target: ZBTB33 (Zinc Finger and BTB Domain Containing 33 (ZBTB33))

Alternative Name: Kaiso (ZBTB33 Products)

Synonyms: kaiso antibody, ZNF-kaiso antibody, ZNF348 antibody, AW260253 antibody, E130014G12Rik antibody, Kaiso antibody, Znf-kaiso antibody, RGD1566309 antibody, zinc finger and BTB domain containing 33 S homeolog antibody, zinc finger and BTB domain containing 33 antibody, zbtb33.S antibody, ZBTB33 antibody, Zbtb33 antibody

Background: Background: Transcriptional regulator Kaiso possesses bimodal DNA-binding specificity and binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. Kaiso contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Kaiso may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. [taken from NCBI Entrez Gene (Gene ID: 10009)].

Gene ID: 10009

NCBI Accession: NP_006768

UniProt: Q86T24