PYGL antibody (AA 797-847)

Catalog No. ABIN7450622

The Rabbit Polyclonal anti-PYGL antibody has been validated for WB and IP. It is suitable to detect PYGL in samples from Human and Mouse.

Quick Overview for PYGL antibody (AA 797-847) (ABIN7450622)

Target: PYGL (phosphorylase, Glycogen, Liver (PYGL))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYGL antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-PYGL Antibody

Binding Specificity: AA 797-847

Purpose: Rabbit anti-PYGL Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 797 and 847

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PYGL

Target: PYGL (phosphorylase, Glycogen, Liver (PYGL))

Alternative Name: PYGL

Background: Background: Glycogen phosphorylase, liver form, (PYGL) encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues [taken from NCBI Entrez Gene (Gene ID: 5836)].

Gene ID: 5836

NCBI Accession: NP_002854

UniProt: P06737

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process