TNKS1BP1 antibody (AA 1679-1729)

Catalog No. ABIN7450796

Product Details anti-TNKS1BP1 Antibody

Target: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Binding Specificity: AA 1679-1729

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNKS1BP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-TAB182 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1679 and 1729

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TNKS1BP1

Target: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Alternative Name: TAB182 (TNKS1BP1 Products)

Synonyms: TAB182 antibody, Tab182 antibody, mKIAA1741 antibody, tankyrase 1 binding protein 1 antibody, 182 kDa tankyrase-1-binding protein antibody, TNKS1BP1 antibody, LOC100625088 antibody, Tnks1bp1 antibody

Background: Background: TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Gene ID: 85456

NCBI Accession: NP_203754

UniProt: Q9C0C2