UBQLN4 antibody (AA 1-50)

Catalog No. ABIN7450868

The Rabbit Polyclonal anti-UBQLN4 antibody has been validated for WB and IP. It is suitable to detect UBQLN4 in samples from Human.

Quick Overview for UBQLN4 antibody (AA 1-50) (ABIN7450868)

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBQLN4 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-UBQLN4 Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-UBQLN4/CIP75/Ubiquilin 4 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Alternative Name: UBQLN4/CIP75/Ubiquilin 4

Background: Background: Ubiquilin-4 (UBQLN4) plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). It mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. UBQLN4 Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). It acts as an adapter protein that recruits UBQLN1 to the autophagy machinery and mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205) [taken from NCBI Entrez Gene (Gene ID: 56893)].

Gene ID: 56893

UniProt: Q9NRR5