VRK1 antibody (AA 346-396)

Catalog No. ABIN7450901

The Rabbit Polyclonal anti-VRK1 antibody has been validated for WB and IP. It is suitable to detect VRK1 in samples from Human.

Quick Overview for VRK1 antibody (AA 346-396) (ABIN7450901)

Target: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VRK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-VRK1 Antibody

Binding Specificity: AA 346-396

Purpose: Rabbit anti-VRK1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 346 and 396

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for VRK1

Target: VRK1 (Vaccinia Related Kinase 1 (VRK1))

Alternative Name: VRK1

Background: Background: Vaccinia-related kinase 1 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.VRK1 is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 Molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This protein, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN [taken from NCBI Entrez Gene (Gene ID: 7443)].

Gene ID: 7443

UniProt: Q99986