Importin 9 antibody (AA 991-1041)

Catalog No. ABIN7450998

This anti-Importin 9 antibody is a Rabbit Polyclonal antibody detecting Importin 9 in WB and IP. Suitable for Human and Mouse.

Quick Overview for Importin 9 antibody (AA 991-1041) (ABIN7450998)

Target: Importin 9 (IPO9)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 9 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Importin 9 Antibody

Binding Specificity: AA 991-1041

Purpose: Rabbit anti-IPO9 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 991 and 1041

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Importin 9

Target: Importin 9 (IPO9)

Alternative Name: IPO9

Background: Background: Importin-9 (IPO9) functions in nuclear protein import as a nuclear transport receptor. IPO9 serves as receptor for nuclear localization signals (NLS) in cargo substrates. It is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). IPO9 mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. It prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. IPO9 may also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6 [taken from the Universal Protein Resource (UniProt) Q96P70].

Gene ID: 55705

UniProt: Q96P70

Pathways: Protein targeting to Nucleus