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MDC1 antibody (AA 900-950)

This Rabbit Polyclonal antibody specifically detects MDC1 in IP. It exhibits reactivity toward Mouse.

Catalog No. ABIN7451086

Quick Overview for MDC1 antibody (AA 900-950) (ABIN7451086)

Target

See all MDC1 Antibodies

MDC1 (Mdc1 (MDC1))

Reactivity

60
43
16
12
11
2
1
1

Mouse

Host

Rabbit

Clonality

Polyclonal

Conjugate

28
6
6
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1

This MDC1 antibody is un-conjugated

Application

58
22
14
13
13
13
12
10
9
5
3
2
1
1
1

Immunoprecipitation (IP)

Discover our top product MDC1 Primary Antibody

Binding Specificity
21

15

10

8

5

3

2

2

2

1

1

1

1

1

1

1

1
AA 900-950

Purpose

Rabbit anti-Mdc1/Nfbd1 Antibody, Affinity Purified

Purification

Affinity Purified

Immunogen

Between AA 900 and 950

Isotype

IgG
anti-Mdc1 (MDC1) (AA 1-100) antibody
MDC1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) antibody
MDC1 Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) (AA 1-350) antibody
MDC1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) (AA 31-130) antibody
MDC1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) (N-Term) antibody
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 unconjugated

anti-Mdc1 (MDC1) (N-Term) antibody (HRP)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 HRP

anti-Mdc1 (MDC1) (N-Term) antibody (FITC)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 FITC

anti-Mdc1 (MDC1) (N-Term) antibody (Biotin)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Biotin

anti-Mdc1 (MDC1) (N-Term) antibody (PE)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 PE

anti-Mdc1 (MDC1) (N-Term) antibody (APC)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 APC

Application Notes

IP: 2 - 10 μg/mg lysate
WB: Not recommended. ABIN7451086 has not performed satisfactorily when used for WB of Mdc1/Nfbd1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of Mdc1/Nfbd1.

Restrictions

For Research Use only
Concentration

1000 μg/mL

Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C

Expiry Date

12 months
Target

MDC1 (Mdc1 (MDC1))

Alternative Name

Mdc1/Nfbd1

Background

Background: Mediator of DNA damage checkpoint protein 1 (Mdc1) is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. It may serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. It is also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis [taken from the Universal Protein Resource (UniProt) Q5PSV9].

Gene ID

240087

NCBI Accession

NP_001010833

UniProt

Q5PSV9

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