RFWD2 antibody (AA 100-150)

Catalog No. ABIN7451219

The Rabbit Polyclonal anti-RFWD2 antibody is suitable to detect RFWD2 in samples from Human. It has been validated for IP.

Quick Overview for RFWD2 antibody (AA 100-150) (ABIN7451219)

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFWD2 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-RFWD2 Antibody

Binding Specificity: AA 100-150

Purpose: Rabbit anti-COP1/RFWD2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 100 and 150

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-COP1/RFWD2 antibody ABIN7450133.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RFWD2

Target: RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))

Alternative Name: COP1/RFWD2

Background: Background: Constitutive photomorphogenic protein 1 (COP1) has been characterized in plants as a RING-finger-containing protein that functions to repress plant photomorphogenesis. In mammals, COP1 has been identified as an E3 ubiquitin ligase that negatively regulates p53 protein levels in unstressed cells. In response to DNA damage COP1 is phosphorylated by the ataxia telangiectasia mutated (ATM) protein kinase and is rapidly degraded releasing p53 to exert its tumor suppressor activities.

Gene ID: 64326

NCBI Accession: NP_071902

UniProt: Q8NHY2

Pathways: Photoperiodism