TGFBR2 antibody (AA 475-525)

Catalog No. ABIN7451525

The Rabbit Polyclonal anti-TGFBR2 antibody is suitable to detect TGFBR2 in samples from Human. It has been validated for IP.

Quick Overview for TGFBR2 antibody (AA 475-525) (ABIN7451525)

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBR2 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-TGFBR2 Antibody

Binding Specificity: AA 475-525

Purpose: Rabbit anti-TGFBR2 Antibody, Affinity Purified

Predicted Reactivity: Rat,Chicken

Purification: Affinity Purified

Immunogen: Between AA 475 and 525

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TGFBR2

Target: TGFBR2 (Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2))

Alternative Name: TGFBR2

Background: Background: TGF-beta type II receptor (TGFBR2) is a transmembrane serine/threonine kinase that complexes with the TGF-beta type I serine/threonine kinase receptor (TGFBR1) to form the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. The TGFBR complex transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.The TGFBR is also involved in non-canonical, SMAD-independent TGF-beta signaling pathways [taken from the Universal Protein Resource (UniProt) P37173].

Gene ID: 7048

NCBI Accession: NP_003233

UniProt: P37173