Calreticulin antibody (AA 367-417)

Catalog No. ABIN7451672

The Rabbit Polyclonal anti-Calreticulin antibody has been validated for WB and IP. It is suitable to detect Calreticulin in samples from Human and Mouse.

Quick Overview for Calreticulin antibody (AA 367-417) (ABIN7451672)

Target: Calreticulin (CALR)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calreticulin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Calreticulin Antibody

Binding Specificity: AA 367-417

Purpose: Rabbit anti-Calreticulin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 367 and 417

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Calreticulin

Target: Calreticulin (CALR)

Alternative Name: Calreticulin

Background: Background: Calreticulin is identified as a multifunctional protein that acts as a lectin chaperone and calcium binding protein. Calreticulin is found in the lumen of the endoplasmic reticulum and nucleus. In the nucleus, Calreticulin appears to function as a coregulator of nuclear hormone receptors. Increased autoantibody titers against calreticulin are associated with systemic lupus.

Gene ID: 811

NCBI Accession: NP_004334

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response