CIZ1 antibody (AA 848-898)

Catalog No. ABIN7451705

The Rabbit Polyclonal anti-CIZ1 antibody has been validated for WB and IP. It is suitable to detect CIZ1 in samples from Human.

Quick Overview for CIZ1 antibody (AA 848-898) (ABIN7451705)

Target: CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIZ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-CIZ1 Antibody

Binding Specificity: AA 848-898

Purpose: Rabbit anti-CIZ1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 848 and 898

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CIZ1

Target: CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))

Alternative Name: CIZ1

Background: Background: CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

Gene ID: 25792

NCBI Accession: NP_036259

UniProt: Q9ULV3

Pathways: Maintenance of Protein Location