ERCC3 antibody (AA 732-782)
Quick Overview for ERCC3 antibody (AA 732-782) (ABIN7451774)
Target
See all ERCC3 AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 732-782
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Purpose
- Rabbit anti-ERCC3 Antibody, Affinity Purified
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Predicted Reactivity
- Rat,Bovine,Orangutan
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Purification
- Affinity Purified
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Immunogen
- between AA 732 and 782
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Isotype
- IgG
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Application Notes
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Restrictions
- For Research Use only
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Concentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Expiry Date
- 12 months
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- ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))
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Alternative Name
- ERCC3
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Background
- Background: ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.
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Gene ID
- 2071
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NCBI Accession
- NP_000113
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UniProt
- P19447
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Pathways
- DNA Damage Repair
Target
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