FAS antibody (AA 285-335)

Catalog No. ABIN7451780

The Rabbit Polyclonal anti-FAS antibody has been validated for WB and IP. It is suitable to detect FAS in samples from Human.

Quick Overview for FAS antibody (AA 285-335) (ABIN7451780)

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAS antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-FAS Antibody

Binding Specificity: AA 285-335

Purpose: Rabbit anti-FAS Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 285 and 335

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for FAS

Target: FAS (TNF Receptor Superfamily, Member 6 (FAS))

Alternative Name: FAS

Background: Background: Tumor necrosis factor receptor superfamily member 6, FAS, functions as the receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated FAS receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) which mediate apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both [taken from the Universal Protein Resource (UniProt) P25445].

Gene ID: 355

NCBI Accession: NP_000034

UniProt: P25445

Pathways: p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity