TAB2 antibody (AA 500-550)

Catalog No. ABIN7452084

This anti-TAB2 antibody is a Rabbit Polyclonal antibody detecting TAB2 in WB and IP. Suitable for Human and Mouse.

Quick Overview for TAB2 antibody (AA 500-550) (ABIN7452084)

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-TAB2 Antibody

Binding Specificity: AA 500-550

Purpose: Rabbit anti-TAB2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 500 and 550

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TAB2

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Alternative Name: TAB2

Background: Background: TAB2 (TGF-beta-activated kinase 1and MAP3K7-binding protein 2) functions as an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. TAB2 forms a kinase complex with TRAF6, MAP3K7 and TAB1, and thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts [taken from NCBI Entrez Gene (GeneID: 23118)].

Gene ID: 23118

NCBI Accession: NP_055908

UniProt: Q9NYJ8

Pathways: TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway