Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 2150-2200) antibody

Catalog No. ABIN7452441

The Rabbit Polyclonal anti-Spectrin, Beta, Non-erythrocytic 2 antibody (ABIN7452441) specifically detects Spectrin, Beta, Non-erythrocytic 2 in IP. The antibody is reactive with Human samples.

Quick Overview for Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 2150-2200) antibody (ABIN7452441)

Target: Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunoprecipitation (IP)

Product Details

Binding Specificity: AA 2150-2200

Purpose: Rabbit anti-SPTBN2/SCA5 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 2150 and 2200

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-SPTBN2/SCA5 antibody ABIN7450766.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details

Target: Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

Alternative Name: SPTBN2/SCA5

Background: Background: SPTBN2/SCA5 is a member of the beta spectrin gene family and a subunit of the spectrin cytoskeletal scaffolding protein that links the plasma membrane to cytoskeletal actin and functions in cellular shape and organelle organization. SPTBN2/SCA5 has been identified as a Golgi- and vesicle-associated spectrin. Mutations in SPTBN2/SCA5 cause spinocerebellar ataxia type 5 (SCA5), an autosomal dominant disease characterized by progressive incoordination of gait, hand, speech, and eye movements.

Gene ID: 6712

NCBI Accession: NP_008877

UniProt: O15020

Pathways: Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis