SUFUH antibody (AA 325-375)

Catalog No. ABIN7452445

This Rabbit Polyclonal antibody specifically detects SUFUH in IP. It exhibits reactivity toward Human.

Quick Overview for SUFUH antibody (AA 325-375) (ABIN7452445)

Target: SUFUH (Suppressor of Fused Homolog (SUFUH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUFUH antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-SUFUH Antibody

Binding Specificity: AA 325-375

Purpose: Rabbit anti-SuFu Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 325 and 375

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-SuFu antibody ABIN7452074.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for SUFUH

Target: SUFUH (Suppressor of Fused Homolog (SUFUH))

Alternative Name: SuFu

Background: Background: Suppressor of fused (SuFu) is a negative regulator of the hedgehog and beta-catenin signaling pathway. It down-regulates GLI1-mediated transactivation of target genes and is part of a corepressor complex that acts on DNA-bound GLI1. SuFu may also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Additionally, SuFu sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein [taken from the Universal Protein Resource (UniProt) Q9UMX1].

Gene ID: 51684

NCBI Accession: NP_057253

UniProt: Q9UMX1

Pathways: Hedgehog Signaling, Tube Formation, Maintenance of Protein Location