KIAA1524 antibody (N-Term)

Catalog No. ABIN7452647

Product Details anti-KIAA1524 Antibody

Target: KIAA1524

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KIAA1524 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Mouse anti-CIP2A Monoclonal Antibody, Affinity Purified [2A1-9A4]

Purification: Affinity Purified

Immunogen: Amino terminal one-third of the CIP2A (GeneID 57650) recombinant protein

Clone: 2A1-9A4

Isotype: IgG

Application Details

Application Notes:

IP: 20 μL/mg lysate

WB: 17:40:00

Restrictions: For Research Use only

Handling

Concentration: 40 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for KIAA1524

Target: KIAA1524

Alternative Name: CIP2A (KIAA1524 Products)

Synonyms: CIP2A antibody, p90 antibody, AA408511 antibody, AU018569 antibody, Cip2a antibody, Kiaa1524 antibody, KIAA1524 antibody, LOC100222895 antibody, RGD1310335 antibody, cell proliferation regulating inhibitor of protein phosphatase 2A antibody, RIKEN cDNA C330027C09 gene antibody, KIAA1524 antibody, cell proliferation regulating inhibitor of protein phosphatase 2A L homeolog antibody, CONSTANS interacting protein 2a antibody, CIP2A antibody, C330027C09Rik antibody, KIAA1524 antibody, cip2a.L antibody, CIP2a antibody, cip2a antibody, Cip2a antibody

Background: Background: CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.

Gene ID: 57650

NCBI Accession: NP_065941

UniProt: Q8TCG1