DKC1 antibody (AA 340-390)

Catalog No. ABIN7452754

This Rabbit Polyclonal antibody specifically detects DKC1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for DKC1 antibody (AA 340-390) (ABIN7452754)

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-DKC1 Antibody

Binding Specificity: AA 340-390

Purpose: Rabbit anti-DKC1 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,D. melanogaster,Chicken

Purification: Affinity Purified

Immunogen: between AA 340 and 390

Isotype: IgG

Application Details

Application Notes:

IP: 5 - 15 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DKC1

Target: DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

Alternative Name: DKC1

Background: Background: Dyskeratosis congenita 1(DKC1) is also known as dyskerin. DKC1 is required for ribosome biogenesis and telomere maintenance. It is a probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. DKC1 is also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Defects in DKC1 are a cause of dyskeratosis congenita X-linked recessive (XDKC), a rare progressive bone marrow failure syndrome [taken from the Universal Protein Resource (UniProt) O60832].

Gene ID: 1736

NCBI Accession: NP_001354

UniProt: O60832

Pathways: Telomere Maintenance