Exonuclease 1 antibody (AA 796-846)

Catalog No. ABIN7452757

This Rabbit Polyclonal antibody specifically detects Exonuclease 1 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Exonuclease 1 antibody (AA 796-846) (ABIN7452757)

Target: Exonuclease 1 (EXO1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exonuclease 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Exonuclease 1 Antibody

Binding Specificity: AA 796-846

Purpose: Rabbit anti-Exonuclease 1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 796 and 846

Isotype: IgG

Application Details

Application Notes:

IP: 5 - 15 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Exonuclease 1

Target: Exonuclease 1 (EXO1)

Alternative Name: Exonuclease 1

Background: Background: Exonuclease 1 is a 5'-3' double-stranded DNA exonuclease which may also possess a cryptic 3'-5' double-stranded DNA exonuclease activity. Exonuclease 1 functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. It also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Exonuclease 1 is required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes and is essential for male and female meiosis [taken from the Universal Protein Resource (UniProt) Q9UQ84].

Gene ID: 9156

NCBI Accession: NP_006018

UniProt: Q9UQ84

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response