Exportin 7 antibody (AA 1-50)

Catalog No. ABIN7452835

This Rabbit Polyclonal antibody specifically detects Exportin 7 in WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for Exportin 7 antibody (AA 1-50) (ABIN7452835)

Target: Exportin 7 (XPO7)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 7 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Exportin 7 Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-RanBP16 Antibody, Affinity Purified

Predicted Reactivity: Chicken,Orangutan

Purification: Affinity Purified

Immunogen: between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Exportin 7

Target: Exportin 7 (XPO7)

Alternative Name: RanBP16

Background: Background: RanBP16 mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. RanBP16 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [taken from the Universal Protein Resource (UniProt) Q9UIA9].

Gene ID: 23039

UniProt: Q9UIA9