ALS2 antibody (AA 1250-1300)

Catalog No. ABIN7453027

This Rabbit Polyclonal antibody specifically detects ALS2 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for ALS2 antibody (AA 1250-1300) (ABIN7453027)

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALS2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALS2 Antibody

Binding Specificity: AA 1250-1300

Purpose: Rabbit anti-Alsin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1250 and 1300

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ALS2

Target: ALS2 (Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2))

Alternative Name: Alsin

Background: Background: Alsin contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. Alsin localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in the gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis [taken from NCBI Entrez Gene (Gene ID: 57679)].

Gene ID: 57679

NCBI Accession: NP_065970

UniProt: Q96Q42

Pathways: Skeletal Muscle Fiber Development