TRAF6 antibody (AA 472-522)

Catalog No. ABIN7453229

The Rabbit Polyclonal anti-TRAF6 antibody has been validated for WB. It is suitable to detect TRAF6 in samples from Human.

Quick Overview for TRAF6 antibody (AA 472-522) (ABIN7453229)

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRAF6 Antibody

Binding Specificity: AA 472-522

Purpose: Rabbit anti-TRAF6 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 472 and 522

Isotype: IgG

Application Details

Application Notes:

IP: Not recommended

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TRAF6

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Alternative Name: TRAF6

Background: Background: TNF receptor-associated factor 6 (TRAF6) is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. TRAF6 also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. TRAF6 leads to the activation of NF-kappa-B and JUN. TRAF6 may be essential for the formation of functional osteoclasts, and it regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. TRAF6 also seems to play a role in dendritic cells (DCs) maturation and/or activation. TRAF6 represses c-Myb-mediated transactivation, in B-lymphocytes. TRAF6 is an adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor [taken from the Universal Protein Resource (UniProt) Q9Y4K3].

Gene ID: 7189

NCBI Accession: NP_004611

UniProt: Q9Y4K3

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway