CBS antibody (AA 1-50)

Catalog No. ABIN7453425

This anti-CBS antibody is a Rabbit Polyclonal antibody detecting CBS in WB, IP and IHC (fp). Suitable for Human.

Quick Overview for CBS antibody (AA 1-50) (ABIN7453425)

Target: CBS (Cystathionine-beta-Synthase (CBS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBS antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-CBS Antibody

Binding Specificity: AA 1-50

Purpose: Rabbit anti-CBS Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 1 and 50

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Alternative Name: CBS

Background: Background: Cystathionine beta-synthase (CBS) is the only known pyridoxal phosphate-dependent enzyme that contains heme. It is an important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).Cystathionine beta-synthase (CBS) acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. CBS is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor [taken from NCBI Entrez Gene (Gene ID: 875)].

Gene ID: 875

UniProt: P35520