TBL1XR1 antibody (AA 100-150)

Catalog No. ABIN7453451

The Rabbit Polyclonal anti-TBL1XR1 antibody is suitable to detect TBL1XR1 in samples from Human and Mouse. It has been validated for WB, IP and IHC (fp).

Quick Overview for TBL1XR1 antibody (AA 100-150) (ABIN7453451)

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBL1XR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Product Details anti-TBL1XR1 Antibody

Binding Specificity: AA 100-150

Purpose: Rabbit anti-TBLR1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 100 and 150

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for TBL1XR1

Target: TBL1XR1 (Transducin (Beta)-Like 1 X-Linked Receptor 1 (TBL1XR1))

Alternative Name: TBLR1

Background: Background: TBLR1 is a six WD-40 repeat protein with high sequence homology to TBL1 (transducin beta-like protein 1) and is part of the SMRT (silencing mediator of retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor) complexes that interact with nuclear receptors and repress transcription. Biochemical characterization of SMRT and N-CoR complexes demonstrate that SMRT and N-CoR are present in complexes that include HDAC3 (histone deacetylase 3), TBL1, and TBLR1. Association with HDAC3 indicates that these complexes may repress transcription through histone deacetylation and chromatin remodeling.

Gene ID: 79718

NCBI Accession: NP_078941

UniProt: Q9BZK7

Pathways: Regulation of Lipid Metabolism by PPARalpha