RAPGEF2 antibody (AA 975-1025)

Catalog No. ABIN7453596

This anti-RAPGEF2 antibody is a Rabbit Polyclonal antibody detecting RAPGEF2 in WB, IHC (fp) and IP. Suitable for Human.

Quick Overview for RAPGEF2 antibody (AA 975-1025) (ABIN7453596)

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPGEF2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunoprecipitation (IP)

Product Details anti-RAPGEF2 Antibody

Binding Specificity: AA 975-1025

Purpose: Rabbit anti-PDZ-GEF1 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Dog

Purification: Affinity Purified

Immunogen: between AA 975 and 1025

Isotype: IgG

Application Details

Application Notes:

IHC: 1:1,000 to 1:5,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RAPGEF2

Target: RAPGEF2 (Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))

Alternative Name: PDZ-GEF1

Background: Background: PDZ-GEF1 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity.

Gene ID: 9693

NCBI Accession: NP_055062

UniProt: Q9Y4G8

Pathways: Neurotrophin Signaling Pathway